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KMID : 0387419990100020047
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Korean Society of Oriental Neuropsychiatry
1999 Volume.10 No. 2 p.47 ~ p.57
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Effects of Peppermint Oil on Apoptosis of Astrocytes
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Lee Sung-Ryull
Kim Tae-Heon
Lyu Yeoung-Su
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Abstract
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Recently, essential oils are used for aromatherapy. Most essential oils are said to be anti-bacterial; some may be anti-viral or anti-fungal. I investigated the effects of peppermint pure essential oil on the heat shock-induced apoptosis in human astrocyte cell line CCF-STTGI. In previous studies, heat shock has been reported to induce the apoptosis or programmed cell death through the activation of caspase-3. We studied the heat shock-induced apoptosis through flow cytometry, DNA electrophoresis, and giemsa staining. Interestingly, these events were inhibited by pretreatment of peppermint pure essential oils in CCF-STTGl cells. Peppermint oil also inhibited the heat shock-induced apoptosis in primary cultured rat astrocytes. In addition, this Peppermint essential oil inhibited the heat shock-induced activation of caspase-3. These results suggest that peppermint pure essential oils may modulate the apoptosis through the activation of the interleukin-I -converting enzyme-like protease.
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KEYWORD
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peppermint oil, Dementia, Apoptosis, Astrocytes
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